Harmonizing Maternal and Infant Biospecimen Collection and Processing for Research

Philip CE, Faysal H, Quinney SK, Sadovsky Y, Haas DM.

Biopreservation and Biobanking. 2026.

We conducted a descriptive review of protocols and standard operating procedures from major United States and international maternal–infant biobanks to assess harmonization of pre-analytical handling across specimen types. Despite some residual variability, core processing principles—collection timing, temperature control, centrifugation, aliquoting, and long-term storage—were highly consistent, indicating that meaningful harmonization is already largely in place. These findings suggest that barriers to cross-biobank collaboration lie more in metadata capture and data integration than in laboratory procedures, making existing biospecimen resources readily usable for collaborative research.

https://doi.org/10.1177/19475535261453120

Centralised Identification of Early-Gestation Biospecimens to Support Early-Onset Pre-Eclampsia Prediction

Philip CE, Faysal H, Quinney SK, Feng S, Haas DM.

BJOG: An International Journal of Obstetrics & Gynaecology. 2026;133(7):1505-1506.

Predicting early-onset pre-eclampsia depends on biospecimens collected early in gestation, which are typically dispersed across many independent biobanks and difficult to locate. This correspondence shows how a centralised, searchable repository can identify early-gestation maternal samples across biobanks and link them to clinical metadata, enabling investigators to assemble adequately powered cohorts without duplicate collection. Centralised biospecimen identification is presented as a practical step toward collaborative, biomarker-driven prediction of early-onset pre-eclampsia.

https://doi.org/10.1111/1471-0528.70196

Facilitating global collaborations for pregnancy and pediatric biomarker research through a biobank database: the Collaborative Online Perinatal & Pediatric Repository project

Faysal H, Quinney SK, Haas DM.

American Journal of Obstetrics & Gynecology MFM. 2024;6(3):101304.

Biomarker research in pregnancy and pediatrics is hampered by fragmented access to biospecimens held across many separate biobanks with differing catalogues and metadata. The Collaborative Online Perinatal & Pediatric Repository (COPPER) project addresses this gap with a centralised, searchable database that aggregates information on biobanks and their specimens—including blood, cord blood, urine, placental tissue, breast milk, and DNA/genomic data—filterable by specimen, participant, and collection attributes. By improving discoverability of existing resources, COPPER aims to facilitate global collaborations, reduce redundant collection, and accelerate maternal–pediatric biomarker research.

https://doi.org/10.1016/j.ajogmf.2024.101304